Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKD3 | O94806 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.32 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.32 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | ACACB | O00763 | 5/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8779357 | 0.88 | GPR88 (0.32) | GPR88 | |
| SCHEMBL8779185 | 0.88 | ACACB (0.37) | GAAHTTRAB9AHPGDHSD17B10 | |
| SCHEMBL8779424 | 0.86 | MAPK8 (0.37) | MAPK8MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8779219 | 0.85 | ACACB (0.34) | USP2HPGDKDM4EHSD17B10ACACB | |
| SCHEMBL8779132 | 0.84 | ACACB (0.34) | PRKD3MAPK8MAPTHTTHSD17B10 | |
| SCHEMBL8779023 | 0.83 | KDM4E (0.36) | MAPTSMN1; SMN2SMPD1KDM4ECA2 | |
| SCHEMBL8779296 | 0.82 | MEN1 (0.33) | HPGDACACBALDH1A1 | |
| SCHEMBL8779309 | 0.81 | L3MBTL1 (0.39) | MAPTL3MBTL1ALDH1A1POLB | |
| SCHEMBL8881891 | 0.81 | MAPT (0.36) | MAPTNPC1TP53GAAHTT | |
| SCHEMBL8779211 | 0.80 | MEN1 (0.40) | MAPTNPC1RAB9ASMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0661269-B1 | Substituted heterocyclic carboxylic acid amides, their preparation and their use as medicaments | HOECHST AG (DE) | 1997-03-26 | — | — | EP | disclosed |
| EP-0661269-A1 | Substituted heterocyclic carboxylic acid amides, their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-07-05 | — | — | EP | disclosed |