Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HPGDS | O60760 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.31 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8779270 | 0.89 | CNR2 (0.31) | CNR2 | |
| SCHEMBL8779424 | 0.84 | MAPK8 (0.37) | L3MBTL1POLBMAPK1MAPTALDH1A1 | |
| SCHEMBL8779132 | 0.82 | ACACB (0.34) | MAPTCYP2C19ALDH1A1 | |
| SCHEMBL8779178 | 0.81 | PRKD3 (0.33) | L3MBTL1POLBMAPTALDH1A1 | |
| SCHEMBL8779023 | 0.81 | KDM4E (0.36) | MAPTCYP1A2 | |
| SCHEMBL8883734 | 0.81 | L3MBTL1 (0.40) | L3MBTL1POLBMAPK1MAPTHPGDS | |
| SCHEMBL8779244 | 0.80 | LTA4H (0.44) | — | |
| SCHEMBL8779211 | 0.80 | MEN1 (0.40) | L3MBTL1MAPK1MAPTCYP2C9CYP1A2 | |
| SCHEMBL8779296 | 0.80 | MEN1 (0.33) | ALDH1A1 | |
| SCHEMBL8779185 | 0.79 | ACACB (0.37) | MAPK1EPHX2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0661269-B1 | Substituted heterocyclic carboxylic acid amides, their preparation and their use as medicaments | HOECHST AG (DE) | 1997-03-26 | — | — | EP | disclosed |
| EP-0661269-A1 | Substituted heterocyclic carboxylic acid amides, their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-07-05 | — | — | EP | disclosed |