Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 4/20 | 0.40 |
| ▸ | PARP15 | Q460N3 | 3/20 | 0.40 |
| ▸ | CDK2 | P24941 | 11/20 | 0.39 |
| ▸ | CDK1 | P06493 | 4/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 9/20 | 0.37 |
| ▸ | CCNA1 | P78396 | 8/20 | 0.37 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.34 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8779237 | 0.84 | LOX (0.36) | CDK2CDK1 | |
| SCHEMBL8883607 | 0.82 | PARP10 (0.41) | PARP10PARP15CDK2CDK1CNR2 | |
| SCHEMBL8779424 | 0.80 | MAPK8 (0.37) | PARP10 | |
| SCHEMBL8779132 | 0.78 | ACACB (0.34) | ADORA3 | |
| SCHEMBL8779225 | 0.78 | PARP15 (0.40) | PARP10PARP15CDK2CNR2CCNA2 | |
| SCHEMBL8779023 | 0.77 | KDM4E (0.36) | — | |
| SCHEMBL8779178 | 0.77 | PRKD3 (0.33) | — | |
| SCHEMBL8779309 | 0.77 | L3MBTL1 (0.39) | CNR2 | |
| SCHEMBL8786517 | 0.77 | PARP15 (0.41) | PARP10PARP15CNR2PARP2 | |
| SCHEMBL8779244 | 0.76 | LTA4H (0.44) | PARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0661269-B1 | Substituted heterocyclic carboxylic acid amides, their preparation and their use as medicaments | HOECHST AG (DE) | 1997-03-26 | — | — | EP | disclosed |
| EP-0661269-A1 | Substituted heterocyclic carboxylic acid amides, their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-07-05 | — | — | EP | disclosed |