Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 6/20 | 0.43 |
| ▸ | PPIA | P62937 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.39 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.39 |
| ▸ | PTPN6 | P29350 | 2/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | RXRB | P28702 | 1/20 | 0.38 |
| ▸ | RXRG | P48443 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.37 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.37 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.37 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.37 |
| ▸ | KDM5A | P29375 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8779187 | 0.92 | MRGPRX4 (0.37) | MAOBPPIAPTPN1PTPN2PTPN6 | |
| SCHEMBL8779285 | 0.89 | KDM4E (0.40) | MAOBALDH1A1 | |
| SCHEMBL8779269 | 0.89 | L3MBTL1 (0.46) | MAOBPPIAPTPN1ALDH1A1SPHK2 | |
| SCHEMBL8779331 | 0.89 | MMP1 (0.41) | MAOBRXRARXRBRXRGMRGPRX4 | |
| SCHEMBL8779168 | 0.87 | SMN1; SMN2 (0.40) | MAOBPPIAALDH1A1 | |
| SCHEMBL8779406 | 0.87 | LTA4H (0.44) | PPIA | |
| SCHEMBL8785593 | 0.87 | MAOB (0.41) | MAOBPPIAPTPN1PTPN2PTPN6 | |
| SCHEMBL8785286 | 0.86 | PPIA (0.49) | MAOBPPIAPTPN1PTPN2PTPN6 | |
| SCHEMBL8779238 | 0.85 | CYP1A2 (0.36) | ALDH1A1 | |
| SCHEMBL8779316 | 0.85 | MME (0.39) | MAOBPPIAPTPN1PTPN2PTPN6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0661269-B1 | Substituted heterocyclic carboxylic acid amides, their preparation and their use as medicaments | HOECHST AG (DE) | 1997-03-26 | — | — | EP | disclosed |
| EP-0661269-A1 | Substituted heterocyclic carboxylic acid amides, their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-07-05 | — | — | EP | disclosed |