Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 1/20 | 0.39 |
| ▸ | ACE | P12821 | 1/20 | 0.39 |
| ▸ | CPA1 | P15085 | 1/20 | 0.39 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.39 |
| ▸ | TACR1 | P25103 | 2/20 | 0.36 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.35 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 5/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 5/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 5/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 5/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 5/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 5/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.35 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.35 |
| ▸ | PPIA | P62937 | 1/20 | 0.35 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8779316 | 0.92 | MME (0.39) | MMEACECPA1ACE2PTPN2 | |
| SCHEMBL8779312 | 0.92 | L3MBTL1 (0.44) | MRGPRX4PTPN1PPIAALDH1A1GAA | |
| SCHEMBL8779187 | 0.85 | MRGPRX4 (0.37) | MMEACECPA1ACE2TACR1 | |
| SCHEMBL8779134 | 0.85 | CARM1 (0.38) | ADAM17PTGER1ALDH1A1L3MBTL1 | |
| SCHEMBL8779232 | 0.85 | GSK3B (0.39) | ALDH1A1 | |
| SCHEMBL8884327 | 0.84 | MME (0.38) | MMEACECPA1ACE2TACR1 | |
| SCHEMBL8779153 | 0.84 | CARM1 (0.40) | MMEACECPA1ACE2ALDH1A1 | |
| SCHEMBL8779198 | 0.84 | LTA4H (0.46) | MMEACECPA1ACE2ALDH1A1 | |
| SCHEMBL8779265 | 0.84 | TRPV1 (0.38) | ADAM17MRGPRX4 | |
| SCHEMBL8779192 | 0.82 | KDM4E (0.39) | MRGPRX4CYP2D6ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0661269-B1 | Substituted heterocyclic carboxylic acid amides, their preparation and their use as medicaments | HOECHST AG (DE) | 1997-03-26 | — | — | EP | disclosed |
| EP-0661269-A1 | Substituted heterocyclic carboxylic acid amides, their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-07-05 | — | — | EP | disclosed |