Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 11/20 | 0.38 |
| ▸ | CIT | O14578 | 7/20 | 0.36 |
| ▸ | LARS1 | Q9P2J5 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8779231 | 0.89 | CARM1 (0.33) | AAK1CYP3A4 | |
| SCHEMBL8779210 | 0.88 | CIT (0.30) | CIT | |
| SCHEMBL8779223 | 0.85 | AAK1 (0.39) | AAK1CITLARS1 | |
| SCHEMBL8779220 | 0.84 | AAK1 (0.40) | AAK1CITLARS1 | |
| SCHEMBL8882710 | 0.83 | AAK1 (0.38) | AAK1CITLARS1CYP3A4 | |
| SCHEMBL8779334 | 0.82 | LNPEP (0.42) | AAK1CITLARS1 | |
| SCHEMBL8779284 | 0.82 | NFKB1 (0.32) | — | |
| SCHEMBL8779292 | 0.82 | CARM1 (0.35) | AAK1CYP3A4 | |
| SCHEMBL8779229 | 0.81 | IRAK4 (0.40) | AAK1 | |
| SCHEMBL8779212 | 0.80 | HPGD (0.38) | AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0661269-B1 | Substituted heterocyclic carboxylic acid amides, their preparation and their use as medicaments | HOECHST AG (DE) | 1997-03-26 | — | — | EP | disclosed |
| EP-0661269-A1 | Substituted heterocyclic carboxylic acid amides, their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-07-05 | — | — | EP | disclosed |