Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23956955 | 0.94 | ALDH1A1 (0.53) | ALDH1A1MAPK1L3MBTL1NOTUMLMNA | |
| SCHEMBL8571445 | 0.85 | ALDH1A1 (0.43) | ALDH1A1MAPK1L3MBTL1KMT2AMEN1 | |
| SCHEMBL1912656 | 0.85 | ALDH1A1 (0.53) | ALDH1A1MAPK1L3MBTL1LMNATDP1 | |
| SCHEMBL8570425 | 0.83 | RAB9A (0.49) | ALDH1A1MAPK1L3MBTL1KMT2AMEN1 | |
| SCHEMBL7442298 | 0.82 | ALDH1A1 (0.50) | ALDH1A1MAPK1L3MBTL1NOTUMLMNA | |
| SCHEMBL3399492 | 0.81 | ALDH1A1 (0.49) | ALDH1A1MAPK1L3MBTL1NOTUMLMNA | |
| SCHEMBL18780918 | 0.79 | ALDH1A1 (0.53) | ALDH1A1MAPK1L3MBTL1NOTUMLMNA | |
| SCHEMBL18780944 | 0.77 | ALDH1A1 (0.44) | ALDH1A1MAPK1L3MBTL1NOTUMLMNA | |
| SCHEMBL1177836 | 0.77 | ALDH1A1 (0.73) | ALDH1A1MAPK1L3MBTL1NOTUMLMNA | |
| SCHEMBL4870701 | 0.77 | LMNA (0.54) | ALDH1A1L3MBTL1LMNAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0391673-B2 | Preparation of glutaric acid derivatives | PFIZER LTD (GB) | 1997-04-02 | — | — | EP | disclosed |
| US-5192800-A | Hypotensive agents | PFIZER INC. (US) | 1993-03-09 | — | — | US | disclosed |
| CN-1016778-B | spiro-substituted glutaric acid monoamides | PFIZER LTD (GB) | 1992-05-27 | — | — | CN | disclosed |
| EP-0274234-B1 | SPIRO-SUBSITUTED GLUTARAMIDE DIURETIC AGENTS | Pfizer Limited (GB) | 1991-09-11 | — | — | EP | disclosed |
| US-5030654-A | Glutaramide diuretic agents | PFIZER INC. (US) | 1991-07-09 | — | — | US | disclosed |
| EP-0391673-A1 | Preparation of glutaric acid derivatives | Pfizer Limited (GB) | 1990-10-10 | — | — | EP | disclosed |
| EP-0274234-A2 | Spiro-subsituted glutaramide diuretic agents | Pfizer Limited (GB) | 1988-07-13 | — | — | EP | disclosed |
| CN-87107371-A | The glutaramide diuretic agents of spiral shell-replacement | — | 1988-07-06 | — | — | CN | disclosed |