Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.46 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8426550 | 0.81 | L3MBTL1 (0.46) | KMT2AL3MBTL1SMN1; SMN2PAX8TLR9 | |
| SCHEMBL21183514 | 0.79 | KMT2A (0.49) | KMT2AL3MBTL1SMN1; SMN2PAX8TLR9 | |
| SCHEMBL4333889 | 0.79 | ALDH1A1 (0.46) | L3MBTL1SMN1; SMN2POLBHTTCA12 | |
| SCHEMBL4601280 | 0.78 | PAX8 (0.50) | KMT2ASMN1; SMN2PAX8TLR9POLB | |
| SCHEMBL8779753 | 0.77 | TSPO (0.53) | KMT2ASMN1; SMN2PAX8TLR9POLB | |
| SCHEMBL829847 | 0.75 | ALDH1A1 (0.46) | KMT2ASMN1; SMN2POLBESR1ALDH1A1 | |
| SCHEMBL19974868 | 0.74 | PAX8 (0.45) | KMT2AL3MBTL1PAX8TLR9MAPK1 | |
| SCHEMBL713040 | 0.74 | PTGIR (0.51) | KMT2AL3MBTL1SMN1; SMN2PAX8TLR9 | |
| SCHEMBL11206279 | 0.74 | CA1 (0.50) | KMT2AL3MBTL1PAX8TLR9MAPK1 | |
| SCHEMBL5655590 | 0.72 | CA12 (0.43) | KMT2AL3MBTL1SMN1; SMN2PAX8TLR9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150119376-A2 | CYCLOALKENYL ARYL DERIVATIVES FOR CETP INHIBITOR | CHONG KUN DANG PHARMACEUTICAL CORP. (KR) | 2015-04-30 | — | — | US | disclosed |
| US-20140031335-A1 | CYCLOALKENYL ARYL DERIVATIVES FOR CETP INHIBITOR | CHONG KUN DANG PHARMACEUTICAL CORP. (KR) | 2014-01-30 | — | — | US | disclosed |
| EP-0525197-B1 | 3-BENZYLIDENE-1-CARBAMOYL-2-PYRROLIDONE ANALOGS | SHIONOGI & CO (JP) | 1997-08-27 | — | — | EP | disclosed |
| US-5319100-A | Antiinflammatory agent which does not cause stomach diseases | SHIONOGI SEIYAKU KABUSHIKI KAISHA (JP) | 1994-06-07 | — | — | US | disclosed |
| US-5319099-A | Antiinflammatory agent which does not cause stomach diseases | SHIONOGI SEIYAKU KABUSHIKI KAISHA (JP) | 1994-06-07 | — | — | US | disclosed |
| EP-0525197-A1 | 3-BENZYLIDENE-1-CARBAMOYL-2-PYRROLIDONE ANALOG | SHIONOGI SEIYAKU KABUSHIKI KAISHA (JP) | 1993-02-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150119376-A2 | CYCLOALKENYL ARYL DERIVATIVES FOR CETP INHIBITOR | CETP, MTTP, LCAT | KMT2A 2470/4885L3MBTL1 3110/4885SMN1; SMN2 4881/4885 |
| US-20140031335-A1 | CYCLOALKENYL ARYL DERIVATIVES FOR CETP INHIBITOR | CETP, MTTP, LCAT | KMT2A 2470/4885L3MBTL1 3110/4885SMN1; SMN2 4881/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.