Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8779737 | 0.80 | TRPM8 (0.46) | TRPM8KMT2AMEN1TP53LMNA | |
| SCHEMBL27352619 | 0.78 | TSHR (0.43) | KMT2AMEN1TP53LMNAL3MBTL1 | |
| SCHEMBL8779792 | 0.76 | TRPM8 (0.50) | TRPM8KMT2AMEN1TP53LMNA | |
| SCHEMBL12465941 | 0.74 | ACHE (0.38) | TRPM8LMNACYP3A4KDM4EALDH1A1 | |
| SCHEMBL8779621 | 0.73 | TRPM8 (0.51) | TRPM8KMT2AMEN1TP53LMNA | |
| SCHEMBL8779541 | 0.71 | TRPM8 (0.51) | TRPM8KMT2AMEN1TP53LMNA | |
| SCHEMBL3650052 | 0.71 | TRPM8 (0.42) | TRPM8KMT2AMEN1TP53LMNA | |
| SCHEMBL8187602 | 0.70 | TRPM8 (0.50) | TRPM8KMT2AMEN1TP53LMNA | |
| SCHEMBL1029152 | 0.70 | TRPM8 (0.50) | TRPM8KMT2ALMNAALDH1A1 | |
| Benzene SCHEMBL28335658 | 0.70 | TRPM8 (0.50) | TRPM8KMT2ALMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0525197-B1 | 3-BENZYLIDENE-1-CARBAMOYL-2-PYRROLIDONE ANALOGS | SHIONOGI & CO (JP) | 1997-08-27 | — | — | EP | disclosed |
| US-5319100-A | Antiinflammatory agent which does not cause stomach diseases | SHIONOGI SEIYAKU KABUSHIKI KAISHA (JP) | 1994-06-07 | — | — | US | disclosed |
| US-5319099-A | Antiinflammatory agent which does not cause stomach diseases | SHIONOGI SEIYAKU KABUSHIKI KAISHA (JP) | 1994-06-07 | — | — | US | disclosed |
| EP-0525197-A1 | 3-BENZYLIDENE-1-CARBAMOYL-2-PYRROLIDONE ANALOG | SHIONOGI SEIYAKU KABUSHIKI KAISHA (JP) | 1993-02-03 | — | — | EP | disclosed |