Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9175691 | 0.86 | ALDH1A1 (0.44) | TRPM8LMNAALDH1A1KDM4EKMT2A | |
| SCHEMBL8634893 | 0.85 | LMNA (0.47) | TRPM8LMNAALDH1A1KDM4EKMT2A | |
| SCHEMBL8779621 | 0.83 | TRPM8 (0.51) | TRPM8LMNAALDH1A1KMT2AMEN1 | |
| SCHEMBL8779737 | 0.80 | TRPM8 (0.46) | TRPM8LMNAALDH1A1KDM4EKMT2A | |
| SCHEMBL5512049 | 0.78 | ALDH1A1 (0.47) | LMNAALDH1A1KMT2AMEN1TP53 | |
| SCHEMBL9714447 | 0.77 | ALDH1A1 (0.39) | TRPM8LMNAALDH1A1KDM4EKMT2A | |
| SCHEMBL8779768 | 0.76 | TRPM8 (0.43) | TRPM8LMNAALDH1A1KDM4EKMT2A | |
| SCHEMBL7601412 | 0.76 | ALDH1A1 (0.44) | TRPM8LMNAALDH1A1KDM4EKMT2A | |
| SCHEMBL11652965 | 0.75 | TRPM8 (0.56) | TRPM8LMNAALDH1A1KDM4EKMT2A | |
| SCHEMBL7194821 | 0.74 | ALDH1A1 (0.41) | TRPM8LMNAALDH1A1KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0525197-B1 | 3-BENZYLIDENE-1-CARBAMOYL-2-PYRROLIDONE ANALOGS | SHIONOGI & CO (JP) | 1997-08-27 | — | — | EP | disclosed |
| US-5319100-A | Antiinflammatory agent which does not cause stomach diseases | SHIONOGI SEIYAKU KABUSHIKI KAISHA (JP) | 1994-06-07 | — | — | US | disclosed |
| US-5319099-A | Antiinflammatory agent which does not cause stomach diseases | SHIONOGI SEIYAKU KABUSHIKI KAISHA (JP) | 1994-06-07 | — | — | US | disclosed |
| EP-0525197-A1 | 3-BENZYLIDENE-1-CARBAMOYL-2-PYRROLIDONE ANALOG | SHIONOGI SEIYAKU KABUSHIKI KAISHA (JP) | 1993-02-03 | — | — | EP | disclosed |