Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | LOX | P28300 | 2/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8783392 | 0.89 | MEN1 (0.47) | PKMMEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL8942652 | 0.84 | PKM (0.44) | PKMMEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL29280967 | 0.75 | HTR2A (0.68) | ALDH1A1HTR2AHTR2CGAAAKR1C3 | |
| SCHEMBL29280971 | 0.74 | HDAC6 (0.49) | PKMMEN1KMT2AALDH1A1NAMPT | |
| SCHEMBL8783039 | 0.73 | TDP1 (0.49) | MEN1KMT2AALDH1A1EPHX2ALOX5 | |
| SCHEMBL8942817 | 0.73 | GAA (0.42) | PKMMEN1KMT2ALOXNAMPT | |
| SCHEMBL8783271 | 0.72 | SIGMAR1 (0.57) | MEN1KMT2AALDH1A1HSD17B10NPC1 | |
| SCHEMBL999837 | 0.71 | CXCR2 (0.57) | ALDH1A1HTR2AHTR2CAKR1C3 | |
| SCHEMBL8783294 | 0.71 | MEN1 (0.57) | PKMMEN1KMT2AALDH1A1EPHX2 | |
| SCHEMBL8783388 | 0.70 | ALOX5 (0.48) | MEN1KMT2AALDH1A1EPHX2ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0595995-B1 | ARYLAMIDOALKYL- AND ARYLAMINOALKYL-N-HYDROXYUREA COMPOUNDS AND -N-HYDROXYFORMAMIDE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY | ABBOTT LAB (US) | 1997-01-15 | — | — | EP | disclosed |
| US-5514702-A | Arylamidoalkyl-N-hydroxyurea compounds having lipoxygenase inhibitory activity | ABBOTT LABORATORIES (US) | 1996-05-07 | — | — | US | disclosed |