Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 2/20 | 0.40 |
| ▸ | LOX | P28300 | 2/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | FLT4 | P35916 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8942652 | 0.89 | PKM (0.44) | NAMPTLOXHTR6PKMKMT2A | |
| SCHEMBL8783392 | 0.84 | MEN1 (0.47) | GAATP53MAPTTHRBSMN1; SMN2 | |
| SCHEMBL8942382 | 0.79 | CYP2C9 (0.47) | MAPTKMT2AMEN1KDM4E | |
| SCHEMBL8942712 | 0.79 | PARP14 (0.45) | AKR1C3KMT2AMEN1 | |
| SCHEMBL8942408 | 0.74 | TNKS (0.39) | MAPTAKR1C3RAB9AKMT2AMEN1 | |
| SCHEMBL8942465 | 0.73 | L3MBTL1 (0.49) | ATMKMT2AMEN1CA1CA2 | |
| SCHEMBL8782842 | 0.73 | PKM (0.54) | GAATP53SMN1; SMN2AKR1C3NAMPT | |
| SCHEMBL8942753 | 0.72 | PARP1 (0.52) | GAAMAPTRAB9AKMT2AMEN1 | |
| SCHEMBL8942661 | 0.71 | KMO (0.53) | KMT2AMEN1FAAH | |
| SCHEMBL8942585 | 0.70 | MEN1 (0.42) | GAASMN1; SMN2RAB9AKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5514702-A | Arylamidoalkyl-N-hydroxyurea compounds having lipoxygenase inhibitory activity | ABBOTT LABORATORIES (US) | 1996-05-07 | — | — | US | disclosed |