SCHEMBL8782870

SCHEMBL8782870

COc1ccc(C(=O)c2ccc(OC)cc2-c2ccccc2)c(-c2ccccc2)c1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 3/20 0.57
CYP2C19 P33261 3/20 0.57
HPGD P15428 3/20 0.57
LMNA P02545 2/20 0.57
PGR P06401 2/20 0.57
SLC6A2 P23975 2/20 0.57
CYP3A4 P08684 1/20 0.57
ADORA3 P0DMS8 1/20 0.57
AR P10275 1/20 0.57
CHRM1 P11229 1/20 0.57
ALOX15 P16050 1/20 0.57
TBXA2R P21731 1/20 0.57
ADRA1A P35348 1/20 0.57
HIF1A Q16665 1/20 0.57
NPC1 O15118 1/20 0.56
RAB9A P51151 1/20 0.56
ALDH1A1 P00352 3/20 0.55
CYP2D6 P10635 2/20 0.55
PDE4A P27815 1/20 0.55
MAPK1 P28482 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30739535 0.92 ALDH1A1 (0.68) CYP1A2CYP2C19HPGDLMNAPGR
SCHEMBL6701301 0.90 SMN1; SMN2 (0.63) CYP1A2CYP2C19HPGDLMNAPGR
SCHEMBL22319299 0.88 ALDH1A1 (0.57) CYP1A2CYP2C19HPGDLMNAPGR
SCHEMBL6775841 0.87 KDM4E (0.62) CYP1A2CYP2C19HPGDLMNAPGR
SCHEMBL10876312 0.84 LMNA (0.63) CYP1A2CYP2C19HPGDLMNAPGR
SCHEMBL2869174 0.84 NPC1 (0.58) CYP1A2CYP2C19HPGDLMNAPGR
SCHEMBL4963334 0.84 BCAT2 (0.53) CYP1A2CYP2C19HPGDLMNAPGR
SCHEMBL4392160 0.83 NPC1 (0.53) CYP1A2CYP2C19HPGDLMNAPGR
SCHEMBL27634808 0.83 TAS1R3 (0.55) CYP1A2CYP2C19HPGDLMNAPGR
SCHEMBL27704684 0.82 ALDH1A1 (0.59) CYP1A2CYP2C19HPGDLMNAPGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0560898-B1 PHOTOCHROMIC NAPHTHOPYRANS PPG INDUSTRIES INC (US) 1997-03-26 EP disclosed
US-5340857-A Ophthalmic lenses, plastic transparencies PPG INDUSTRIES, INC. (US) 1994-08-23 US disclosed
EP-0560898-A4 PHOTOCHROMIC NAPHTHOPYRANS 1993-11-18 EP disclosed
EP-0560898-A1 PHOTOCHROMIC NAPHTHOPYRANS. PPG INDUSTRIES INC (US) 1993-09-22 EP disclosed
US-5244602-A Photochromic articles comprising polymerized organic host material and naphthopyran PPG INDUSTRIES, INC. (US) 1993-09-14 US disclosed
WO-1992009593-A1 PHOTOCHROMIC NAPHTHOPYRANS PPG INDUSTRIES, INC. (US) 1992-06-11 WO disclosed