Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 2/20 | 0.39 |
| ▸ | EDNRA | P25101 | 2/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | FPR1 | P21462 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | BRS3 | P32247 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6580558 | 0.82 | SLC22A12 (0.42) | EDNRBEDNRAAURKACSNK1EGSK3A | |
| SCHEMBL8792168 | 0.80 | EDNRA (0.41) | EDNRBEDNRAAURKACSNK1EGSK3A | |
| SCHEMBL8325612 | 0.76 | LMNA (0.43) | AURKACSNK1EGSK3AGSK3BLMNA | |
| SCHEMBL7501396 | 0.75 | EDNRA (0.45) | EDNRBEDNRALMNAKMT2AALDH1A1 | |
| SCHEMBL8434873 | 0.75 | EDNRA (0.45) | EDNRBEDNRAAURKACSNK1EGSK3A | |
| SCHEMBL8785853 | 0.75 | AURKA (0.38) | AURKACSNK1EGSK3AGSK3BLMNA | |
| SCHEMBL7502700 | 0.74 | EDNRA (0.43) | EDNRBEDNRAALDH1A1SMN1; SMN2BRS3 | |
| SCHEMBL3839001 | 0.73 | EDNRA (0.45) | EDNRBEDNRAAURKACSNK1EGSK3A | |
| SCHEMBL6580208 | 0.72 | EDNRB (0.45) | EDNRBEDNRABRS3 | |
| SCHEMBL6580278 | 0.71 | EDNRA (0.45) | EDNRBEDNRAALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0804435-A1 | NOVEL IMIDAZOLE DERIVATIVES, METHOD FOR PREPARING SAME, NOVEL INTERMEDIATES THUS OBTAINED, MEDICINAL APPLICATIONS OF SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | ROUSSEL UCLAF (FR) | 1997-11-05 | — | — | EP | disclosed |
| WO-1996004275-A1 | NOVEL IMIDAZOLE DERIVATIVES, METHOD FOR PREPARING SAME, NOVEL INTERMEDIATES THUS OBTAINED, MEDICINAL APPLICATIONS OF SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | ROUSSEL UCLAF (FR) | 1996-02-15 | — | — | WO | disclosed |