Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.42 |
| ▸ | EDNRA | P25101 | 3/20 | 0.42 |
| ▸ | EDNRB | P24530 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | BRS3 | P32247 | 1/20 | 0.41 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8325612 | 0.92 | LMNA (0.43) | SLC22A12LMNABRS3SLC29A1SMN1; SMN2 | |
| SCHEMBL8792168 | 0.91 | EDNRA (0.41) | EDNRAEDNRBLMNABRS3SLC29A1 | |
| SCHEMBL6580573 | 0.85 | BRS3 (0.42) | SLC22A12LMNABRS3SLC29A1SMN1; SMN2 | |
| SCHEMBL7501396 | 0.84 | EDNRA (0.45) | EDNRAEDNRBLMNABRS3SMN1; SMN2 | |
| SCHEMBL8434873 | 0.84 | EDNRA (0.45) | SLC22A12EDNRAEDNRBBRS3SMN1; SMN2 | |
| SCHEMBL3839001 | 0.82 | EDNRA (0.45) | EDNRAEDNRBBRS3SMN1; SMN2AURKA | |
| SCHEMBL8792176 | 0.82 | EDNRB (0.39) | EDNRAEDNRBLMNABRS3SMN1; SMN2 | |
| SCHEMBL6580208 | 0.81 | EDNRB (0.45) | EDNRAEDNRBBRS3 | |
| SCHEMBL7502700 | 0.80 | EDNRA (0.43) | EDNRAEDNRBBRS3SMN1; SMN2 | |
| SCHEMBL6580278 | 0.80 | EDNRA (0.45) | EDNRAEDNRBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5811444-A | IMIDAZOLE DERIVATIVES | ROUSSEL UCLAF (FR) | 1998-09-22 | — | — | US | claimed |
| EP-0804435-B1 | NOVEL IMIDAZOLE DERIVATIVES, METHOD FOR PREPARING SAME, NOVEL INTERMEDIATES THUS OBTAINED, MEDICINAL APPLICATIONS OF SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | AVENTIS PHARMA SA (FR) | 2004-03-10 | — | — | EP | disclosed |
| US-5932741-A | TREATING ILLNESSES RESULTING FROM ABNORMAL STIMULATION OF ENDOTHELIN RECEPTORS | HOECHST MARION ROUSSEL (FR) | 1999-08-03 | — | — | US | disclosed |
| US-5856509-A | HYPOTENSIVE AGENTS | ROUSSEL UCLAF (FR) | 1999-01-05 | — | — | US | disclosed |
| US-5811444-A | IMIDAZOLE DERIVATIVES | ROUSSEL UCLAF (FR) | 1998-09-22 | — | — | US | disclosed |