Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 4/20 | 0.41 |
| ▸ | EDNRB | P24530 | 3/20 | 0.41 |
| ▸ | BRS3 | P32247 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6580558 | 0.91 | SLC22A12 (0.42) | EDNRAEDNRBBRS3LMNAAURKA | |
| SCHEMBL8325612 | 0.83 | LMNA (0.43) | BRS3LMNAAURKACSNK1EGSK3A | |
| SCHEMBL8792176 | 0.80 | EDNRB (0.39) | EDNRAEDNRBBRS3LMNAAURKA | |
| SCHEMBL7501396 | 0.79 | EDNRA (0.45) | EDNRAEDNRBBRS3LMNA | |
| SCHEMBL8434873 | 0.79 | EDNRA (0.45) | EDNRAEDNRBBRS3AURKACSNK1E | |
| SCHEMBL6580573 | 0.78 | BRS3 (0.42) | BRS3LMNAAURKACSNK1EGSK3A | |
| SCHEMBL3839001 | 0.77 | EDNRA (0.45) | EDNRAEDNRBBRS3AURKACSNK1E | |
| SCHEMBL7496916 | 0.77 | EDNRA (0.54) | EDNRAEDNRBBRS3 | |
| SCHEMBL6580208 | 0.76 | EDNRB (0.45) | EDNRAEDNRBBRS3 | |
| SCHEMBL6580278 | 0.75 | EDNRA (0.45) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0804435-A1 | NOVEL IMIDAZOLE DERIVATIVES, METHOD FOR PREPARING SAME, NOVEL INTERMEDIATES THUS OBTAINED, MEDICINAL APPLICATIONS OF SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | ROUSSEL UCLAF (FR) | 1997-11-05 | — | — | EP | disclosed |
| WO-1996004275-A1 | NOVEL IMIDAZOLE DERIVATIVES, METHOD FOR PREPARING SAME, NOVEL INTERMEDIATES THUS OBTAINED, MEDICINAL APPLICATIONS OF SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | ROUSSEL UCLAF (FR) | 1996-02-15 | — | — | WO | disclosed |