Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.31 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.31 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.31 |
| ▸ | CTSL | P07711 | 1/20 | 0.31 |
| ▸ | CTSB | P07858 | 1/20 | 0.31 |
| ▸ | CTSS | P25774 | 1/20 | 0.31 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.30 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20679918 | 0.77 | NAMPT (0.46) | NAMPTSLC40A1LOXL2 | |
| SCHEMBL3511229 | 0.74 | CYP2C19 (0.40) | NAMPTSLC40A1NLRP3 | |
| SCHEMBL6182721 | 0.72 | LOXL2 (0.40) | NAMPTLOXL2 | |
| SCHEMBL20679889 | 0.72 | CYP2A6 (0.41) | MAPK8SLC40A1 | |
| SCHEMBL8797268 | 0.71 | FBP1 (0.38) | NAMPTSLC40A1NLRP3 | |
| SCHEMBL28240365 | 0.70 | MRGPRX4 (0.44) | — | |
| SCHEMBL28656315 | 0.68 | MEN1 (0.32) | SLC40A1 | |
| SCHEMBL30817869 | 0.67 | — | — | |
| SCHEMBL502516 | 0.66 | ABCC9 (0.44) | NAMPTSLC40A1NLRP3PDPK1 | |
| SCHEMBL3300930 | 0.66 | IDO1 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0772606-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003392-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |