Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15858815 | 0.84 | TSHR (0.56) | TSHRCYP3A4ALDH1A1LMNACYP1A2 | |
| SCHEMBL9035461 | 0.82 | ALDH1A1 (0.49) | CYP3A4ALDH1A1LMNAMAPTMAPK1 | |
| SCHEMBL9142431 | 0.82 | MASP2 (0.51) | TSHRCYP3A4ALDH1A1LMNAMAPT | |
| SCHEMBL8799443 | 0.81 | TBXAS1 (0.38) | CYP3A4ALDH1A1LMNACYP1A2CYP2D6 | |
| SCHEMBL8800375 | 0.80 | ALDH1A1 (0.47) | TSHRCYP3A4ALDH1A1LMNAMAPT | |
| SCHEMBL875441 | 0.80 | ALDH1A1 (0.56) | ALDH1A1LMNAMAPTTDP1HPGD | |
| SCHEMBL14553797 | 0.80 | TSHR (0.55) | TSHRCYP3A4ALDH1A1LMNACYP1A2 | |
| SCHEMBL11302992 | 0.79 | TSHR (0.58) | TSHRCYP3A4ALDH1A1LMNACYP1A2 | |
| SCHEMBL10498009 | 0.79 | TSHR (0.54) | TSHRCYP3A4ALDH1A1LMNACYP1A2 | |
| SCHEMBL9687621 | 0.77 | TSHR (0.64) | TSHRCYP3A4ALDH1A1LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0482771-B1 | Heterocyclic acids | ZENECA LTD (GB) | 1997-06-18 | — | — | EP | disclosed |
| CN-1034120-C | Pyridine derivatives | ZENECA LTD (GB) | 1997-02-26 | — | — | CN | disclosed |
| EP-0365328-B1 | Pyridine derivatives | ZENECA LTD (GB) | 1996-04-03 | — | — | EP | disclosed |
| US-5410064-A | Thromboxane A2 antagonists and inhibitors of thromboxane A2 synthase | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1995-04-25 | — | — | US | disclosed |
| US-5219874-A | Heterocyclic acids | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-06-15 | — | — | US | disclosed |
| EP-0482771-A2 | Heterocyclic acids | ZENECA LIMITED (GB) | 1992-04-29 | — | — | EP | disclosed |
| US-5053415-A | Antiischemic, antiinflammatory, antiarthritic agents, cardiovascular disorders | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-10-01 | — | — | US | disclosed |
| EP-0365328-A2 | Pyridine derivatives | ZENECA LIMITED (GB) | 1990-04-25 | — | — | EP | disclosed |