Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CCKBR | P32239 | 8/20 | 0.42 |
| ▸ | CCKAR | P32238 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8801216 | 0.91 | CCKBR (0.39) | MAPTCCKBRCCKARUSP2BRD4 | |
| SCHEMBL8804138 | 0.83 | CCKBR (0.42) | CCKBRCCKAR | |
| SCHEMBL8801767 | 0.82 | BRD4 (0.41) | MAPTCCKBRALDH1A1BRD4 | |
| SCHEMBL8801349 | 0.82 | HTT (0.45) | HTTMAPTTSHRCCKBRCCKAR | |
| SCHEMBL8801124 | 0.82 | CCKBR (0.51) | HTTMAPTTSHRCCKBRCCKAR | |
| SCHEMBL8803196 | 0.74 | CCKBR (0.47) | CCKBRCCKAR | |
| SCHEMBL8801220 | 0.72 | ALOX15 (0.40) | MAPTCCKBRCCKARUSP2BRD4 | |
| SCHEMBL8800433 | 0.71 | CCKBR (0.46) | CCKBRCCKAR | |
| SCHEMBL9039585 | 0.68 | CCKBR (0.61) | CCKBR | |
| SCHEMBL8667990 | 0.68 | CCKBR (0.55) | CCKBRCCKAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0763537-A2 | Non-peptidyl Ras farnesyl transferase inhibitors | GENENTECH, INC. (US) | 1997-03-19 | — | — | EP | disclosed |
| EP-0698015-A1 | PREPARATION OF N-CYANODITHIOIMINO-CARBONATES AND 3-MERCAPTO-5-AMINO-1H-1,2,4-TRIAZOLE | GENENTECH, INC. (US) | 1996-02-28 | — | — | EP | disclosed |
| WO-1994026723-A2 | ras FARNESYL TRANSFERASE INHIBITORS | GENENTECH, INC. (US) | 1994-11-24 | — | — | WO | disclosed |