Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.53 |
| ▸ | CYSLTR1 | Q9Y271 | 7/20 | 0.53 |
| ▸ | GPBAR1 | Q8TDU6 | 5/20 | 0.53 |
| ▸ | CYSLTR2 | Q9NS75 | 3/20 | 0.52 |
| ▸ | ALOX5AP | P20292 | 4/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10682896 | 0.91 | ALOX5AP (0.54) | PDE10ACYSLTR1GPBAR1CYSLTR2ALOX5AP | |
| SCHEMBL9490780 | 0.86 | CYSLTR1 (0.50) | PDE10ACYSLTR1GPBAR1CYSLTR2ALOX5AP | |
| SCHEMBL8801993 | 0.85 | PDE10A (0.51) | PDE10ACYSLTR1GPBAR1CYSLTR2ALOX5AP | |
| SCHEMBL9492165 | 0.83 | CYSLTR1 (0.51) | PDE10ACYSLTR1GPBAR1CYSLTR2ALOX5AP | |
| SCHEMBL9493090 | 0.81 | ALOX5 (0.50) | CYSLTR1GPBAR1ALOX5HDAC6 | |
| SCHEMBL9335591 | 0.80 | LTB4R (0.58) | PDE10ACYSLTR1GPBAR1CYSLTR2 | |
| SCHEMBL8965369 | 0.79 | CYSLTR1 (0.49) | CYSLTR1GPBAR1CYSLTR2ALOX5APALOX5 | |
| Hydroxyamine SCHEMBL8967003 | 0.77 | CYSLTR1 (0.43) | PDE10ACYSLTR1GPBAR1CYSLTR2ALOX5AP | |
| SCHEMBL9598096 | 0.77 | ALOX5 (0.52) | CYSLTR1GPBAR1CYSLTR2ALOX5 | |
| SCHEMBL7483348 | 0.76 | PDE10A (0.60) | PDE10ACYSLTR1GPBAR1CYSLTR2ALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0772594-A1 | IMINOXYCARBOXYLATES AND DERIVATIVES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | Abbott Laboratories (US) | 1997-05-14 | — | — | EP | disclosed |
| US-5512581-A | ANTIINFLAMMATORY AGENT | ABBOTT LABORATORIES (US) | 1996-04-30 | — | — | US | disclosed |
| WO-1996002507-A1 | IMINOXYCARBOXYLATES AND DERIVATIVES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | ABBOTT LABORATORIES (US) | 1996-02-01 | — | — | WO | disclosed |