Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 8/20 | 0.50 |
| ▸ | GPBAR1 | Q8TDU6 | 5/20 | 0.50 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.50 |
| ▸ | ALOX5AP | P20292 | 4/20 | 0.49 |
| ▸ | CYSLTR2 | Q9NS75 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8801596 | 0.86 | PDE10A (0.53) | CYSLTR1GPBAR1PDE10AALOX5APCYSLTR2 | |
| SCHEMBL9492132 | 0.83 | HRH3 (0.47) | ALOX5AP | |
| SCHEMBL9492340 | 0.83 | GAA (0.48) | ALOX5 | |
| SCHEMBL8801993 | 0.82 | PDE10A (0.51) | CYSLTR1GPBAR1PDE10AALOX5APCYSLTR2 | |
| SCHEMBL9492165 | 0.80 | CYSLTR1 (0.51) | CYSLTR1GPBAR1PDE10AALOX5APCYSLTR2 | |
| SCHEMBL9487573 | 0.80 | TAOK1 (0.53) | — | |
| SCHEMBL10682896 | 0.80 | ALOX5AP (0.54) | CYSLTR1GPBAR1PDE10AALOX5APCYSLTR2 | |
| SCHEMBL9493090 | 0.79 | ALOX5 (0.50) | CYSLTR1GPBAR1ALOX5HDAC6 | |
| SCHEMBL8965369 | 0.77 | CYSLTR1 (0.49) | CYSLTR1GPBAR1ALOX5APCYSLTR2ALOX5 | |
| Hydroxyamine SCHEMBL8967003 | 0.74 | CYSLTR1 (0.43) | CYSLTR1GPBAR1PDE10AALOX5APCYSLTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0522000-A1 | 5-LIPOXYGENASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-01-13 | — | — | EP | disclosed |
| WO-1991014674-A2 | 5-LIPOXYGENASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1991-10-03 | — | — | WO | disclosed |