SCHEMBL8802608

SCHEMBL8802608

CN1CCCCC1COC(=O)c1nn(C)c2ccccc12

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 9/20 0.57
CHRNA4 P43681 9/20 0.57
CHRNA7 P36544 7/20 0.57
CHRNA5 P30532 3/20 0.57
ELANE P08246 1/20 0.50
KDM4E B2RXH2 1/20 0.50
ADRA2A P08913 1/20 0.47
HTR3E A5X5Y0 1/20 0.47
SLC22A2 O15244 1/20 0.47
HTR3B O95264 1/20 0.47
CHRNA3 P32297 1/20 0.47
HTR3A P46098 1/20 0.47
KCNH2 Q12809 1/20 0.47
HTR3D Q70Z44 1/20 0.47
HTR3C Q8WXA8 1/20 0.47
SLC47A1 Q96FL8 1/20 0.47
CHRM3 P20309 2/20 0.46
ALDH1A1 P00352 1/20 0.46
CYP3A4 P08684 1/20 0.46
TSHR P16473 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7276038 0.79 CHRNB2 (0.58) CHRNB2CHRNA4CHRNA7CHRNA5
SCHEMBL8804474 0.77 KDM4E (0.55) CHRNB2CHRNA4ELANEKDM4EHTR3E
SCHEMBL6946846 0.75 HTR4 (0.52) HTR3ACHRM3
SCHEMBL6705737 0.75 ELANE (0.70) ELANEKDM4E
SCHEMBL7276531 0.74 CNR1 (0.56) CHRNB2CHRNA4CHRNA7CHRNA5ALDH1A1
SCHEMBL7271018 0.74 CNR1 (0.57) CHRNB2CHRNA4CHRNA7CHRNA5
SCHEMBL7271039 0.73 CYP2D6 (0.60) CHRNB2CHRNA4CHRNA7CHRNA5HTR3E
SCHEMBL7269463 0.73 CYP2D6 (0.60) CHRNB2CHRNA4CHRNA7CHRNA5HTR3E
SCHEMBL7269469 0.73 CYP2D6 (0.60) CHRNB2CHRNA4CHRNA7CHRNA5HTR3E
SCHEMBL7277894 0.72 CYP2D6 (0.62) CHRNB2CHRNA4CHRNA7CHRNA5HTR3E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0499995-B1 Piperidine derivatives NISSHIN FLOUR MILLING CO (JP) 1997-01-02 EP disclosed
US-5246945-A 5-hydroxytryptamine antagonist for nervous system disorders NISSHIN FLOUR MILLING CO., LTD. (JP) 1993-09-21 US disclosed
EP-0499995-A2 Piperidine derivatives NISSHIN FLOUR MILLING CO., LTD. (JP) 1992-08-26 EP disclosed