Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOAT2 | O75908 | 1/20 | 0.49 |
| ▸ | ACAT1 | P24752 | 1/20 | 0.49 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.49 |
| ▸ | NMBR | P28336 | 1/20 | 0.35 |
| ▸ | GRPR | P30550 | 1/20 | 0.35 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8804251 | 0.84 | SOAT2 (0.50) | SOAT2ACAT1SOAT1NMBRGRPR | |
| SCHEMBL8804204 | 0.71 | NPC1 (0.43) | — | |
| SCHEMBL8804151 | 0.71 | RAB9A (0.42) | KMT2AGAAMEN1RIPK1 | |
| SCHEMBL8806812 | 0.71 | GAA (0.36) | KMT2AGAAMEN1ALDH1A1 | |
| SCHEMBL8804541 | 0.70 | KMT2A (0.48) | KMT2ATSHRMEN1CYP3A4CYP2C19 | |
| SCHEMBL8805179 | 0.69 | OPRL1 (0.35) | KMT2AGAA | |
| SCHEMBL1119316 | 0.69 | SOAT2 (0.69) | SOAT2ACAT1SOAT1NMBRGRPR | |
| Hydrochloric Acid SCHEMBL15265491 | 0.69 | SOAT2 (0.67) | SOAT2ACAT1SOAT1NMBRGRPR | |
| SCHEMBL8805166 | 0.69 | SSTR4 (0.35) | KMT2AGAAALDH1A1 | |
| SCHEMBL8804984 | 0.68 | GAA (0.38) | ACAT1SOAT1KMT2ATSHRGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0625507-B1 | Urea derivatives and their use as acat inhibitors | NISSHIN FLOUR MILLING CO (JP) | 1997-07-23 | — | — | EP | disclosed |
| US-5621010-A | ANTIHYPERCHOLESTEROLEMIA AND ANTIATHEROSCLEROSIS | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1997-04-15 | — | — | US | disclosed |
| EP-0625507-A2 | Urea derivatives and their use as acat inhibitors | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1994-11-23 | — | — | EP | disclosed |