Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 13/20 | 0.51 |
| ▸ | PPARA | Q07869 | 9/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | PPARD | Q03181 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8808210 | 0.92 | PPARA (0.60) | PPARGPPARAPPARD | |
| SCHEMBL8805915 | 0.88 | PPARA (0.47) | PPARGPPARAGAAPPARD | |
| SCHEMBL8806855 | 0.85 | PPARG (0.63) | PPARGPPARAPPARD | |
| SCHEMBL8805213 | 0.80 | FAAH (0.46) | GAALMNARAB9ANPC1 | |
| SCHEMBL11638476 | 0.76 | GAA (0.71) | GAALMNARAB9ANPC1 | |
| SCHEMBL11636604 | 0.75 | RAB9A (0.51) | GAALMNARAB9ANPC1 | |
| SCHEMBL11638633 | 0.75 | MAOA (0.54) | GAALMNARAB9ANPC1 | |
| SCHEMBL5766871 | 0.74 | LMNA (0.61) | GAALMNARAB9ANPC1 | |
| SCHEMBL1670312 | 0.74 | PPARA (0.69) | PPARGPPARAPPARD | |
| SCHEMBL4993002 | 0.74 | PPARA (0.69) | PPARGPPARAPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0533781-B1 | 3-ARYL-2-HYDROXYPROPIONIC ACID DERIVATIVES AND ANALOGS AS HYPOGLYCEMIC AGENTS | PFIZER (US) | 1997-02-26 | — | — | EP | disclosed |
| US-5438074-A | 3-aryl-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents | PFIZER INC. (US) | 1995-08-01 | — | — | US | disclosed |
| US-5306726-A | 3-aryl-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents | PFIZER INC. (US) | 1994-04-26 | — | — | US | disclosed |
| US-5232945-A | 3-aryl-2-hydroxypropionic acid derivatives and analogs as antihypertensives | PFIZER INC. (US) | 1993-08-03 | — | — | US | disclosed |
| EP-0533781-A1 | 3-ARYL-2-HYDROXYPROPIONIC ACID DERIVATIVES AND ANALOGS AS HYPOGLYCEMIC AGENTS. | PFIZER (US) | 1993-03-31 | — | — | EP | disclosed |
| WO-1991019702-A1 | 3-ARYL-2-HYDROXYPROPIONIC ACID DERIVATIVES AND ANALOGS AS HYPOGLYCEMIC AGENTS | PFIZER INC. (US) | 1991-12-26 | — | — | WO | disclosed |