Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | IL1R1 | P14778 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8804502 | 0.79 | REN (0.41) | KDM4EHTTAGTR1ALDH1A1PTGDR2 | |
| SCHEMBL8805617 | 0.73 | PLA2G2A (0.44) | KDM4ECYP1A2HTTSMN1; SMN2SLC6A2 | |
| SCHEMBL8804876 | 0.72 | REN (0.39) | KDM4EHTTSMN1; SMN2ALDH1A1PTGDR2 | |
| SCHEMBL13142704 | 0.69 | TLR7 (0.49) | KDM4ECYP1A2HTTCYP2D6SLC2A1 | |
| SCHEMBL16484321 | 0.68 | KDM4E (0.67) | KDM4ECYP1A2SLC6A2ALDH1A1CYP2C19 | |
| SCHEMBL9284669 | 0.65 | KHK (0.48) | KDM4EHTTSMN1; SMN2SLC6A2ALDH1A1 | |
| SCHEMBL4957083 | 0.64 | LMNA (0.77) | CYP1A2CYP2D6SMN1; SMN2ALDH1A1CYP3A4 | |
| SCHEMBL9283417 | 0.64 | OXER1 (0.45) | SLC6A2 | |
| SCHEMBL14013710 | 0.63 | KDM4E (0.47) | KDM4ESLC6A2ALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL6374513 | 0.63 | KDM4E (0.57) | KDM4ESLC6A2ALDH1A1MAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0775131-A2 | INDOL, INDAZOL, PYRIDOPYRROL AND PYRIDOPYRAZOL DERIVATIVES WITH ANTI-ASTHMATIC, ANTI-ALLERGIC, ANTI-INFLAMMATORY AND IMMUNOMODULATING EFFECTS | ASTA Medica Aktiengesellschaft (DE) | 1997-05-28 | — | — | EP | disclosed |