Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | HTR1D | P28221 | 2/20 | 0.35 |
| ▸ | HTR1B | P28222 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | SCN1A | P35498 | 1/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8805917 | 0.84 | DRD2 (0.37) | DRD2HTR1AHTR1DHTR1BSLC6A4 | |
| SCHEMBL8806809 | 0.82 | SCN1A (0.35) | DRD2HTR1AHTR1DHTR1BSLC6A4 | |
| SCHEMBL8806639 | 0.80 | ALDH1A1 (0.43) | HSP90AA1HSP90AB1DRD2HTR1AHTR1D | |
| SCHEMBL8805609 | 0.74 | HSP90AA1 (0.37) | HSP90AA1HSP90AB1TRPV1MAPTLMNA | |
| SCHEMBL8807339 | 0.70 | SLC6A4 (0.52) | HTR1ASLC6A4KCNH2PDE3BPDE3A | |
| SCHEMBL8808373 | 0.68 | DRD2 (0.39) | DRD2HTR1AHTR1DHTR1BSLC6A4 | |
| SCHEMBL8805822 | 0.68 | LMNA (0.42) | DRD2HTR1AMAPTLMNAHTT | |
| SCHEMBL8805728 | 0.68 | LMNA (0.44) | DRD2MAPTLMNAHTTALDH1A1 | |
| SCHEMBL8806081 | 0.68 | DRD2 (0.42) | DRD2KDM1AMAPTLMNAHTT | |
| SCHEMBL18513623 | 0.67 | NPC1 (0.39) | DRD2HTR1AHTR1DDRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0583136-B1 | Piperidino-3,4-dihydrocarbostyryl compounds for the treatment of ischemic disorders | KISSEI PHARMACEUTICAL (JP) | 1997-10-08 | — | — | EP | disclosed |
| US-5294718-A | Platelet aggregation inhibitors; antiischemic agents; side effect reduction | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1994-03-15 | — | — | US | disclosed |
| EP-0583136-A2 | Piperidino-3,4-dihydrocarbostyryl compounds for the treatment of ischemic disorders | Kissei Pharmaceutical Co., Ltd. (JP) | 1994-02-16 | — | — | EP | disclosed |