Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 11/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MLNR | O43193 | 1/20 | 0.37 |
| ▸ | HTR3B | O95264 | 1/20 | 0.37 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8805728 | 0.84 | LMNA (0.44) | DRD2LMNAHTTSMN1; SMN2MAPT | |
| SCHEMBL8805822 | 0.84 | LMNA (0.42) | DRD2HTR1AHTR2ALMNAHTT | |
| SCHEMBL8805609 | 0.84 | HSP90AA1 (0.37) | LMNAHTTSMN1; SMN2MAPTMEN1 | |
| SCHEMBL8805973 | 0.81 | PDE3B (0.43) | DRD2LMNAHTTSMN1; SMN2MAPT | |
| SCHEMBL8806081 | 0.81 | DRD2 (0.42) | DRD2HTR2ALMNAHTTSMN1; SMN2 | |
| SCHEMBL8806549 | 0.80 | MAPT (0.51) | LMNAHTTMAPTGAAMEN1 | |
| SCHEMBL8805823 | 0.79 | CRBN (0.44) | DRD2HTTMAPTPGRDRD4 | |
| SCHEMBL8807339 | 0.76 | SLC6A4 (0.52) | HTR1APGRSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8805917 | 0.74 | DRD2 (0.37) | DRD2HTR1AHTR2AMAPTGAA | |
| SCHEMBL19278654 | 0.73 | CA9 (0.52) | PKMCA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0583136-B1 | Piperidino-3,4-dihydrocarbostyryl compounds for the treatment of ischemic disorders | KISSEI PHARMACEUTICAL (JP) | 1997-10-08 | — | — | EP | disclosed |
| US-5294718-A | Platelet aggregation inhibitors; antiischemic agents; side effect reduction | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1994-03-15 | — | — | US | disclosed |
| EP-0583136-A2 | Piperidino-3,4-dihydrocarbostyryl compounds for the treatment of ischemic disorders | Kissei Pharmaceutical Co., Ltd. (JP) | 1994-02-16 | — | — | EP | disclosed |