Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.44 |
| ▸ | HTT | P42858 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 5/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MMP12 | P39900 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8808373 | 0.84 | DRD2 (0.39) | LMNAHTTMAPTTSHRUSP2 | |
| SCHEMBL8805609 | 0.84 | HSP90AA1 (0.37) | LMNAHTTMAPTTSHRUSP2 | |
| SCHEMBL8805822 | 0.84 | LMNA (0.42) | LMNAHTTMAPTTSHRUSP2 | |
| SCHEMBL8805823 | 0.82 | CRBN (0.44) | HTTMAPTPKMDRD2CRBN | |
| SCHEMBL8806081 | 0.81 | DRD2 (0.42) | LMNAHTTMAPTPKMDRD2 | |
| SCHEMBL8805973 | 0.81 | PDE3B (0.43) | LMNAHTTMAPTDRD2SMN1; SMN2 | |
| SCHEMBL8806549 | 0.80 | MAPT (0.51) | LMNAHTTMAPTTSHRALDH1A1 | |
| SCHEMBL8807339 | 0.76 | SLC6A4 (0.52) | CRBNALOX15NPC1PDE3BPDE3A | |
| SCHEMBL8805021 | 0.70 | CRBN (0.39) | TSHRPKMDRD2CRBNALDH1A1 | |
| SCHEMBL8806234 | 0.68 | HSP90AA1 (0.37) | LMNAHTTMAPTTSHRUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0583136-B1 | Piperidino-3,4-dihydrocarbostyryl compounds for the treatment of ischemic disorders | KISSEI PHARMACEUTICAL (JP) | 1997-10-08 | — | — | EP | disclosed |
| US-5294718-A | Platelet aggregation inhibitors; antiischemic agents; side effect reduction | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1994-03-15 | — | — | US | disclosed |
| EP-0583136-A2 | Piperidino-3,4-dihydrocarbostyryl compounds for the treatment of ischemic disorders | Kissei Pharmaceutical Co., Ltd. (JP) | 1994-02-16 | — | — | EP | disclosed |