Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 8/20 | 0.56 |
| ▸ | BCHE | P06276 | 5/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.51 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.48 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8807451 | 0.88 | ACHE (0.55) | ACHEBCHECYP3A4ROCK2MEN1 | |
| SCHEMBL8806850 | 0.86 | MEN1 (0.53) | ACHEBCHECYP3A4ROCK2MEN1 | |
| SCHEMBL4048156 | 0.81 | BCHE (0.54) | ACHEBCHECYP3A4MEN1KMT2A | |
| SCHEMBL4048160 | 0.80 | ABCB1 (0.58) | ACHEBCHECYP3A4MEN1KMT2A | |
| SCHEMBL8806857 | 0.79 | MEN1 (0.48) | ACHEBCHECYP3A4ROCK2MEN1 | |
| SCHEMBL8807326 | 0.78 | BCHE (0.47) | ACHEBCHECYP3A4ROCK2MEN1 | |
| SCHEMBL514870 | 0.77 | KMT2A (0.82) | ACHEBCHECYP3A4MEN1KMT2A | |
| SCHEMBL8812228 | 0.76 | ACHE (0.56) | ACHEBCHEMEN1KMT2AKDM4E | |
| SCHEMBL8807941 | 0.76 | ABCB1 (0.57) | ACHEBCHEMEN1KMT2AKDM4E | |
| SCHEMBL8809414 | 0.75 | ACHE (0.62) | ACHEBCHEMEN1KMT2ASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663179-A | CAN SENSITIZE MULTIDRUG RESISTANT CANCER CELLS TO CHEMOTHERAPEUTIC AGENTS | LABORATOIRES GLAXO SA (FR) | 1997-09-02 | — | — | US | disclosed |
| EP-0649410-B1 | ANILIDE DERIVATIVES | GLAXO LAB SA (FR) | 1997-05-02 | — | — | EP | disclosed |