Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CCR5 | P51681 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8807458 | 0.86 | MEN1 (0.48) | MEN1KMT2ARAB9ANPC1CYP3A4 | |
| SCHEMBL8806840 | 0.79 | ACHE (0.56) | MEN1KMT2AROCK2CYP3A4KDM4E | |
| SCHEMBL8806850 | 0.77 | MEN1 (0.53) | MEN1KMT2ARAB9ANPC1ROCK2 | |
| SCHEMBL8807960 | 0.75 | MAPT (0.43) | MEN1KMT2ARAB9ANPC1MAPT | |
| SCHEMBL8807066 | 0.75 | ABCG2 (0.42) | MEN1KMT2AROCK2CYP3A4MAPT | |
| SCHEMBL8830724 | 0.74 | MAPT (0.66) | MEN1KMT2ARAB9ANPC1CYP3A4 | |
| SCHEMBL8809426 | 0.74 | KMT2A (0.51) | MEN1KMT2ANPC1MAPTMCHR1 | |
| SCHEMBL8807451 | 0.72 | ACHE (0.55) | MEN1KMT2AROCK2CYP3A4MCHR1 | |
| SCHEMBL8806643 | 0.72 | ABCG2 (0.55) | MEN1KMT2ARAB9ANPC1MAPT | |
| SCHEMBL6148751 | 0.71 | KMT2A (0.63) | MEN1KMT2AMAPTPOLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663179-A | CAN SENSITIZE MULTIDRUG RESISTANT CANCER CELLS TO CHEMOTHERAPEUTIC AGENTS | LABORATOIRES GLAXO SA (FR) | 1997-09-02 | — | — | US | disclosed |
| EP-0649410-B1 | ANILIDE DERIVATIVES | GLAXO LAB SA (FR) | 1997-05-02 | — | — | EP | disclosed |