Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 9/20 | 0.55 |
| ▸ | BCHE | P06276 | 6/20 | 0.54 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.54 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.54 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8809414 | 0.89 | ACHE (0.62) | ACHEBCHESIGMAR1KDRMEN1 | |
| SCHEMBL8806840 | 0.88 | ACHE (0.56) | ACHEBCHEOPRM1TMEM97SIGMAR1 | |
| SCHEMBL8806915 | 0.88 | OPRM1 (0.70) | ACHEBCHEOPRM1TMEM97SIGMAR1 | |
| SCHEMBL8807455 | 0.86 | MEN1 (0.53) | MCHR1CYP3A4KDRMEN1KMT2A | |
| SCHEMBL8812228 | 0.84 | ACHE (0.56) | ACHEBCHEMCHR1KDRMEN1 | |
| SCHEMBL8789201 | 0.77 | ABCG2 (0.59) | ACHEBCHEOPRM1TMEM97SIGMAR1 | |
| SCHEMBL8807458 | 0.77 | MEN1 (0.48) | MCHR1CYP3A4MEN1KMT2A | |
| SCHEMBL8806850 | 0.77 | MEN1 (0.53) | ACHEBCHEMCHR1ROCK2CYP3A4 | |
| SCHEMBL8790765 | 0.77 | ABCG2 (0.56) | ACHEBCHEOPRM1TMEM97SIGMAR1 | |
| SCHEMBL8808363 | 0.77 | MAOA (0.46) | ACHEBCHEOPRM1TMEM97SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663179-A | CAN SENSITIZE MULTIDRUG RESISTANT CANCER CELLS TO CHEMOTHERAPEUTIC AGENTS | LABORATOIRES GLAXO SA (FR) | 1997-09-02 | — | — | US | disclosed |
| EP-0649410-B1 | ANILIDE DERIVATIVES | GLAXO LAB SA (FR) | 1997-05-02 | — | — | EP | disclosed |