Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 11/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | SOD1 | P00441 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | HMOX2 | P30519 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4061725 | 0.84 | LMNA (0.44) | MAOBRAB9AHTTL3MBTL1CYP11B1 | |
| SCHEMBL9076409 | 0.83 | MAPT (0.49) | RAB9ACYP11B1NPC1 | |
| SCHEMBL8802961 | 0.83 | DCPS (0.47) | MAOBCYP11B1 | |
| SCHEMBL29468728 | 0.80 | CYP11B1 (0.39) | MAOBHTTCYP11B1MAOA | |
| SCHEMBL29954558 | 0.80 | ENPP2 (0.41) | RAB9AL3MBTL1CYP11B1NPC1ALDH1A1 | |
| SCHEMBL8804838 | 0.75 | NPC1 (0.48) | RAB9AHTTL3MBTL1CYP11B1NPC1 | |
| SCHEMBL8803373 | 0.75 | ALDH1A1 (0.47) | MAOBRAB9AHTTL3MBTL1CYP11B1 | |
| SCHEMBL4058607 | 0.75 | MAPT (0.47) | RAB9AHTTL3MBTL1CYP11B1NPC1 | |
| SCHEMBL24301622 | 0.74 | PARP10 (0.39) | MAOBCYP11B1NOS1 | |
| SCHEMBL2108784 | 0.72 | CYP11B1 (0.43) | CYP11B1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0556813-B1 | Amphoteric tricyclic compounds as antihistaminic and antiallergic agents | HOKURIKU PHARMACEUTICAL (JP) | 1997-11-26 | — | — | EP | disclosed |
| US-5334594-A | Antihistamines, antiallergens | HOKORIKU PHARMACEUTICAL CO., LTD. (JP) | 1994-08-02 | — | — | US | disclosed |
| EP-0556813-A1 | Amphoteric tricyclic compounds as antihistaminic and antiallergic agents | HOKURIKU PHARMACEUTICAL CO., LTD. (JP) | 1993-08-25 | — | — | EP | disclosed |