Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 3/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 7/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.37 |
| ▸ | ULK1 | O75385 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8805822 | 0.84 | LMNA (0.42) | DRD2MEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL8805609 | 0.81 | HSP90AA1 (0.37) | PDE3BPDE3AMEN1ALDH1A1MAPT | |
| SCHEMBL8805728 | 0.81 | LMNA (0.44) | PDE3BPDE3ADRD2ALDH1A1MAPT | |
| SCHEMBL8808373 | 0.81 | DRD2 (0.39) | PDE3ADRD2MEN1ALDH1A1MAPT | |
| SCHEMBL8805823 | 0.79 | CRBN (0.44) | PDE3BPDE3ADRD2ALDH1A1MAPT | |
| SCHEMBL8806081 | 0.78 | DRD2 (0.42) | DRD2MEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL8806549 | 0.77 | MAPT (0.51) | MEN1ALDH1A1MAPTKMT2AKIF11 | |
| SCHEMBL8807339 | 0.73 | SLC6A4 (0.52) | PDE3BPDE3AKIF11 | |
| SCHEMBL30806668 | 0.69 | KIF11 (0.46) | MEN1KMT2AKIF11ULK1LMNA | |
| SCHEMBL8806234 | 0.66 | HSP90AA1 (0.37) | PDE3BPDE3ADRD2MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0583136-B1 | Piperidino-3,4-dihydrocarbostyryl compounds for the treatment of ischemic disorders | KISSEI PHARMACEUTICAL (JP) | 1997-10-08 | — | — | EP | disclosed |
| US-5294718-A | Platelet aggregation inhibitors; antiischemic agents; side effect reduction | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1994-03-15 | — | — | US | disclosed |
| EP-0583136-A2 | Piperidino-3,4-dihydrocarbostyryl compounds for the treatment of ischemic disorders | Kissei Pharmaceutical Co., Ltd. (JP) | 1994-02-16 | — | — | EP | disclosed |