Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 6/20 | 0.56 |
| ▸ | BCHE | P06276 | 5/20 | 0.55 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | ESR1 | P03372 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8809414 | 0.95 | ACHE (0.62) | ACHEBCHEMEN1KMT2AKDR | |
| SCHEMBL8807451 | 0.84 | ACHE (0.55) | ACHEBCHEMCHR1MEN1KMT2A | |
| SCHEMBL8812233 | 0.79 | TAAR1 (0.55) | MEN1NPC1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL8806840 | 0.76 | ACHE (0.56) | ACHEBCHEMCHR1MEN1KMT2A | |
| SCHEMBL8807455 | 0.76 | MEN1 (0.53) | MCHR1MEN1NPC1KMT2AKDR | |
| SCHEMBL14569771 | 0.76 | TSHR (0.69) | ACHEBCHETSHRMEN1KMT2A | |
| SCHEMBL4884072 | 0.75 | TSHR (0.68) | ACHEBCHETSHRMEN1KMT2A | |
| SCHEMBL11875573 | 0.74 | TSHR (0.71) | ACHEBCHEMCHR1TSHRMEN1 | |
| SCHEMBL8809426 | 0.74 | KMT2A (0.51) | MCHR1MEN1NPC1KMT2AKDR | |
| SCHEMBL14569696 | 0.74 | TSHR (0.66) | ACHEBCHETSHRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663179-A | CAN SENSITIZE MULTIDRUG RESISTANT CANCER CELLS TO CHEMOTHERAPEUTIC AGENTS | LABORATOIRES GLAXO SA (FR) | 1997-09-02 | — | — | US | disclosed |
| EP-0649410-B1 | ANILIDE DERIVATIVES | GLAXO LAB SA (FR) | 1997-05-02 | — | — | EP | disclosed |