Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | CA12 | O43570 | 3/20 | 0.51 |
| ▸ | CA1 | P00915 | 3/20 | 0.51 |
| ▸ | CA2 | P00918 | 3/20 | 0.51 |
| ▸ | CA4 | P22748 | 3/20 | 0.51 |
| ▸ | CA9 | Q16790 | 3/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.47 |
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.47 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.47 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.47 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.47 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8807458 | 0.89 | MEN1 (0.48) | KMT2AMEN1NPC1CA12CA1 | |
| SCHEMBL8812233 | 0.78 | TAAR1 (0.55) | KMT2AMEN1NPC1NR1H4MAPT | |
| SCHEMBL8809414 | 0.76 | ACHE (0.62) | KMT2AMEN1KDRMAOB | |
| SCHEMBL8812228 | 0.74 | ACHE (0.56) | KMT2AMEN1NPC1KDRMCHR1 | |
| SCHEMBL8806857 | 0.74 | MEN1 (0.48) | KMT2AMEN1NPC1MCHR1MAPT | |
| SCHEMBL5181024 | 0.72 | THRB (0.60) | KMT2AMEN1NPC1THRBNR1H4 | |
| SCHEMBL30277587 | 0.72 | RAB9A (0.70) | KMT2AMEN1NPC1NR1H4MAOB | |
| SCHEMBL1470249 | 0.72 | KDM4E (0.64) | KMT2AMEN1MAPTHTT | |
| SCHEMBL5182280 | 0.71 | KMT2A (0.59) | KMT2AMEN1NPC1THRBNR1H4 | |
| SCHEMBL8807455 | 0.71 | MEN1 (0.53) | KMT2AMEN1NPC1KDRMCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663179-A | CAN SENSITIZE MULTIDRUG RESISTANT CANCER CELLS TO CHEMOTHERAPEUTIC AGENTS | LABORATOIRES GLAXO SA (FR) | 1997-09-02 | — | — | US | disclosed |
| EP-0649410-B1 | ANILIDE DERIVATIVES | GLAXO LAB SA (FR) | 1997-05-02 | — | — | EP | disclosed |