Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 4/20 | 0.38 |
| ▸ | SQOR | Q9Y6N5 | 4/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.38 |
| ▸ | PDE4A | P27815 | 2/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8808029 | 0.77 | PTPN1 (0.37) | KMT2AMEN1NTSR1ADORA1ESR1 | |
| SCHEMBL8828012 | 0.75 | ADRA2A (0.40) | KMT2AMEN1NTSR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL4564978 | 0.72 | ALDH1A1 (0.53) | KMT2AMEN1L3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL28452051 | 0.68 | MEN1 (0.59) | KMT2AMEN1NTSR1PIM1L3MBTL1 | |
| SCHEMBL6632600 | 0.66 | ALOX15 (0.50) | KMT2AMEN1ALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL11121142 | 0.65 | KMT2A (0.35) | KMT2AMEN1L3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL1146379 | 0.65 | ALDH1A1 (0.53) | KMT2AMEN1PIM1L3MBTL1SQOR | |
| SCHEMBL1146479 | 0.64 | ALDH1A1 (0.52) | KMT2AMEN1L3MBTL1SQORALDH1A1 | |
| SCHEMBL4258084 | 0.64 | LRRK2 (0.47) | PIM1ALDH1A1SMN1; SMN2MAPK1CDC7 | |
| SCHEMBL22208252 | 0.64 | SQOR (0.84) | KMT2AMEN1PIM1L3MBTL1ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5672609-A | POSTMENOPAUSAL SYNDROME; ANTILIPEMIC AND -CARCINOGENIC AGENTS; OSTEOPOROSIS; CARDIOTONIC AGENTS; RESTENOSIS; SIDE EFFECT REDUCTION COMPARED TO ESTROGEN | ELI LILLY AND COMPANY (US) | 1997-09-30 | — | — | US | claimed |