Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 9/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.41 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 2/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL874757 | 0.75 | HDAC1 (0.44) | NAMPTHDAC1KLKB1ROCK2 | |
| SCHEMBL3050217 | 0.67 | HDAC1 (0.47) | NAMPTHDAC1ROCK2 | |
| SCHEMBL875591 | 0.67 | NAMPT (0.46) | NAMPTHDAC1KLKB1 | |
| SCHEMBL3048802 | 0.66 | NAMPT (0.52) | NAMPTHDAC1ROCK2 | |
| SCHEMBL875577 | 0.66 | HDAC1 (0.43) | NAMPTHDAC1KLKB1EPHX1 | |
| SCHEMBL15030902 | 0.66 | NPC1 (0.68) | NAMPTHDAC1 | |
| SCHEMBL875402 | 0.66 | NAMPT (0.45) | NAMPTHDAC1KLKB1ROCK2 | |
| SCHEMBL3042675 | 0.66 | NAMPT (0.45) | NAMPTHDAC1EPHX1 | |
| SCHEMBL3045603 | 0.65 | NAMPT (0.50) | NAMPTHDAC1 | |
| SCHEMBL882752 | 0.64 | NAMPT (0.46) | NAMPTHDAC1KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012038904-A1 | NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |