Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 7/20 | 0.54 |
| ▸ | PSEN2 | P49810 | 7/20 | 0.54 |
| ▸ | APH1B | Q8WW43 | 7/20 | 0.54 |
| ▸ | NCSTN | Q92542 | 7/20 | 0.54 |
| ▸ | APH1A | Q96BI3 | 7/20 | 0.54 |
| ▸ | PSENEN | Q9NZ42 | 7/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ACLY | P53396 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31609293 | 1.00 | PSEN1 (0.54) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8831384 | 0.92 | PSEN1 (0.51) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL31490923 | 0.90 | PSEN1 (0.46) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8831768 | 0.82 | PSEN1 (0.48) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7653099 | 0.81 | HDAC1 (0.43) | — | |
| SCHEMBL1921483 | 0.80 | PSEN1 (0.67) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL15480483 | 0.80 | SIGMAR1 (0.52) | TP53MAPTMAPK1 | |
| SCHEMBL30661726 | 0.80 | SIGMAR1 (0.52) | TP53MAPTMAPK1 | |
| SCHEMBL31609292 | 0.79 | PER2 (0.48) | MAPTMAPK1 | |
| SCHEMBL31609307 | 0.79 | RORA (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1050604-C | Compound with antipsychotic effect | MEIJI SEIKA KABUSHIKA KAISHA (JP) | 2000-03-22 | — | — | CN | disclosed |
| US-5599815-A | SIDE EFFECT REDUCTION | MEIJI SEIKA KABUSHIKI KAISHA (JP) | 1997-02-04 | — | — | US | disclosed |
| CN-1103534-A | Compound with antipsychotic effect | MEIJI SEIKA CO (JP) | 1995-06-07 | — | — | CN | disclosed |
| EP-0635506-A1 | COMPOUND WITH ANTIPSYCHOTIC EFFECT | MEIJI SEIKA KABUSHIKI KAISHA (JP) | 1995-01-25 | — | — | EP | disclosed |