Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 6/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.35 |
| ▸ | ECE1 | P42892 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MDM4 | O15151 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9213848 | 1.00 | TBXAS1 (0.40) | TBXAS1LMNATP53MDM2ECE1 | |
| SCHEMBL9220923 | 0.81 | ECE1 (0.36) | LMNATP53ECE1MEN1KMT2A | |
| SCHEMBL8833239 | 0.81 | ECE1 (0.36) | LMNATP53ECE1MEN1KMT2A | |
| SCHEMBL8833609 | 0.81 | ECE1 (0.38) | ECE1MEN1KMT2AALDH1A1HSD17B10 | |
| SCHEMBL8833217 | 0.80 | ALDH1A1 (0.34) | TBXAS1LMNAECE1ALDH1A1 | |
| SCHEMBL8833195 | 0.80 | LMNA (0.40) | TBXAS1LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL8832597 | 0.79 | ECE1 (0.36) | ECE1MEN1KMT2ACYP19A1 | |
| SCHEMBL8833096 | 0.79 | ECE1 (0.36) | ECE1MEN1KMT2ACYP19A1 | |
| SCHEMBL9213699 | 0.79 | ECE1 (0.36) | ECE1MEN1KMT2ACYP19A1 | |
| SCHEMBL8833793 | 0.78 | ECE1 (0.34) | ECE1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5608056-A | Substituted 3-pyrrolidinylthio-carbapenems as antimicrobial agents | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-03-04 | — | — | US | disclosed |
| EP-0636133-A1 | SUBSTITUTED 3-PYRROLIDINYLTHIO-CARBAPENEMS AS ANTIMICROBIAL AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-02-01 | — | — | EP | disclosed |
| WO-1993021186-A1 | SUBSTITUTED 3-PYRROLIDINYLTHIO-CARBAPENEMS AS ANTIMICROBIAL AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-10-28 | — | — | WO | disclosed |