Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | ANPEP | P15144 | 1/20 | 0.31 |
| ▸ | ARG1 | P05089 | 1/20 | 0.30 |
| ▸ | ARG2 | P78540 | 1/20 | 0.30 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9220610 | 1.00 | SIGMAR1 (0.33) | SIGMAR1MMP2ANPEPARG1ARG2 | |
| SCHEMBL8833282 | 0.85 | SIGMAR1 (0.32) | SIGMAR1 | |
| SCHEMBL9210982 | 0.82 | LMNA (0.36) | MMP2ANPEPCYP19A1 | |
| SCHEMBL8832726 | 0.82 | LMNA (0.36) | MMP2ANPEPCYP19A1 | |
| SCHEMBL9212026 | 0.82 | MMP2 (0.34) | SIGMAR1MMP2ANPEPCYP19A1 | |
| SCHEMBL8832958 | 0.82 | MMP2 (0.34) | SIGMAR1MMP2ANPEPCYP19A1 | |
| SCHEMBL9025949 | 0.81 | SIGMAR1 (0.31) | SIGMAR1MMP2ANPEPCYP19A1 | |
| SCHEMBL8833308 | 0.81 | ALDH1A1 (0.31) | SIGMAR1MMP2ANPEP | |
| SCHEMBL8833468 | 0.80 | SIGMAR1 (0.33) | SIGMAR1 | |
| SCHEMBL8832796 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5608056-A | Substituted 3-pyrrolidinylthio-carbapenems as antimicrobial agents | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-03-04 | — | — | US | disclosed |
| EP-0636133-A1 | SUBSTITUTED 3-PYRROLIDINYLTHIO-CARBAPENEMS AS ANTIMICROBIAL AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-02-01 | — | — | EP | disclosed |
| WO-1993021186-A1 | SUBSTITUTED 3-PYRROLIDINYLTHIO-CARBAPENEMS AS ANTIMICROBIAL AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-10-28 | — | — | WO | disclosed |