Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 9/20 | 0.48 |
| ▸ | BCHE | P06276 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 6/20 | 0.36 |
| ▸ | HTR6 | P50406 | 3/20 | 0.36 |
| ▸ | HTR7 | P34969 | 2/20 | 0.36 |
| ▸ | GABRP | O00591 | 1/20 | 0.36 |
| ▸ | GABRD | O14764 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8840949 | 0.93 | ACHE (0.43) | ACHEBCHEALDH1A1MAPTLMNA | |
| SCHEMBL8840999 | 0.89 | ACHE (0.47) | ACHEBCHEALDH1A1MAPTHTT | |
| SCHEMBL7290309 | 0.83 | ALDH1A1 (0.41) | ACHEBCHEALDH1A1MAPTLMNA | |
| SCHEMBL9738670 | 0.82 | ACHE (0.41) | ACHEBCHEALDH1A1MAPTMEN1 | |
| SCHEMBL7289927 | 0.80 | ALDH1A1 (0.36) | ACHEBCHEALDH1A1MAPTLMNA | |
| SCHEMBL7299533 | 0.80 | ALDH1A1 (0.39) | ACHEBCHEALDH1A1MAPTLMNA | |
| SCHEMBL8580696 | 0.80 | ALDH1A1 (0.48) | ACHEBCHEALDH1A1MAPTLMNA | |
| SCHEMBL10365811 | 0.80 | MAPT (0.41) | ALDH1A1MAPTLMNAMEN1HTT | |
| SCHEMBL9737830 | 0.79 | APP (0.40) | ACHEBCHEALDH1A1MAPTLMNA | |
| SCHEMBL8840963 | 0.79 | GABRP (0.47) | ACHEBCHEALDH1A1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5597918-A | ANXIOLYTIC AGENTS, SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1997-01-28 | — | — | US | disclosed |
| EP-0601184-A1 | FUSED PYRIDAZINE COMPOUND AND PHARMACEUTICAL USE THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1994-06-15 | — | — | EP | disclosed |