Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 7/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
| ▸ | REN | P00797 | 2/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | ITK | Q08881 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 4/20 | 0.31 |
| ▸ | TEC | P42680 | 2/20 | 0.31 |
| ▸ | CD69 | Q07108 | 1/20 | 0.31 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.31 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
| ▸ | FYN | P06241 | 1/20 | 0.31 |
| ▸ | YES1 | P07947 | 1/20 | 0.31 |
| ▸ | LYN | P07948 | 1/20 | 0.31 |
| ▸ | HCK | P08631 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2062792 | 0.90 | SIGMAR1 (0.35) | LMNAALDH1A1SIGMAR1BTKREN | |
| SCHEMBL886101 | 0.87 | REN (0.38) | ALDH1A1POLBSIGMAR1REN | |
| SCHEMBL884456 | 0.87 | MAPK8 (0.35) | MEN1KMT2AALDH1A1REN | |
| SCHEMBL885827 | 0.84 | SMN1; SMN2 (0.38) | LMNAMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL884926 | 0.81 | ALDH1A1 (0.44) | LMNAMEN1KMT2AALDH1A1POLB | |
| SCHEMBL885664 | 0.80 | SLC18A3 (0.38) | POLBSIGMAR1SMN1; SMN2 | |
| SCHEMBL886633 | 0.79 | HDAC1 (0.34) | LMNAALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL2063270 | 0.78 | SIGMAR1 (0.44) | ALDH1A1POLBSIGMAR1HPGD | |
| SCHEMBL2062942 | 0.78 | CYP2D6 (0.37) | ALDH1A1POLBSIGMAR1RENPARP1 | |
| SCHEMBL884275 | 0.77 | ALDH1A1 (0.35) | MEN1KMT2AALDH1A1POLBBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008089005-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-07-24 | — | — | WO | claimed |
| WO-2008089005-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-07-24 | — | — | WO | disclosed |