Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | PTGIR | P43119 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | REN | P00797 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.32 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2062724 | 0.93 | PTGIR (0.34) | ALDH1A1TSHRPTGIRKMT2AMAPT | |
| SCHEMBL884926 | 0.89 | ALDH1A1 (0.44) | ALDH1A1TSHRKMT2ANPC1MAPT | |
| SCHEMBL884303 | 0.89 | KDM4E (0.36) | ALDH1A1TSHRPTGIRKMT2AMAPT | |
| SCHEMBL885548 | 0.87 | BCL9 (0.36) | ALDH1A1KMT2ATP53RENMEN1 | |
| SCHEMBL884402 | 0.87 | PTGIR (0.36) | ALDH1A1TSHRPTGIRKMT2AMAPT | |
| SCHEMBL884549 | 0.85 | REN (0.39) | ALDH1A1TSHRPTGIRKMT2AMAPT | |
| SCHEMBL886063 | 0.85 | ALDH1A1 (0.35) | ALDH1A1TSHRPTGIRKMT2ATP53 | |
| SCHEMBL885904 | 0.83 | HTR1A (0.36) | ALDH1A1TSHRPTGIRKMT2ANPC1 | |
| SCHEMBL2062941 | 0.83 | KDM4E (0.38) | ALDH1A1TSHRPTGIRKMT2AMAPT | |
| SCHEMBL884381 | 0.82 | KMT2A (0.39) | ALDH1A1TSHRPTGIRKMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008089005-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-07-24 | — | — | WO | claimed |
| WO-2008089005-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-07-24 | — | — | WO | disclosed |