Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | GNRHR | P30968 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL885504 | 0.92 | ALDH1A1 (0.42) | ALDH1A1TSHRKMT2AMEN1KDM4E | |
| SCHEMBL884275 | 0.89 | ALDH1A1 (0.35) | ALDH1A1TSHRKMT2AMEN1MAPT | |
| SCHEMBL884303 | 0.87 | KDM4E (0.36) | ALDH1A1TSHRKMT2AKDM4ELMNA | |
| SCHEMBL884600 | 0.86 | KDM4E (0.40) | ALDH1A1TSHRKMT2AMEN1KDM4E | |
| SCHEMBL884626 | 0.86 | PKM (0.42) | ALDH1A1TSHRKMT2AMEN1KDM4E | |
| SCHEMBL884402 | 0.85 | PTGIR (0.36) | ALDH1A1TSHRKMT2AMEN1KDM4E | |
| SCHEMBL884549 | 0.84 | REN (0.39) | ALDH1A1TSHRKMT2AMEN1KDM4E | |
| SCHEMBL884381 | 0.84 | KMT2A (0.39) | ALDH1A1TSHRKMT2AMEN1KDM4E | |
| SCHEMBL884591 | 0.83 | KDM4E (0.39) | ALDH1A1TSHRKMT2AMEN1KDM4E | |
| SCHEMBL2062699 | 0.83 | KMT2A (0.45) | ALDH1A1TSHRKMT2AMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008089005-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-07-24 | — | — | WO | claimed |
| WO-2008089005-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-07-24 | — | — | WO | disclosed |