Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | REN | P00797 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | PIK3R5 | Q8WYR1 | 1/20 | 0.34 |
| ▸ | PIK3R3 | Q92569 | 1/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.34 |
| ▸ | USP19 | O94966 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2063146 | 0.90 | BRD4 (0.38) | MAPK8DRD2DRD4DRD3REN | |
| SCHEMBL884267 | 0.87 | LMNA (0.35) | RENALDH1A1MEN1KMT2A | |
| SCHEMBL884467 | 0.84 | SMN1; SMN2 (0.40) | ALDH1A1KDM4ENPSR1MEN1KMT2A | |
| SCHEMBL884926 | 0.81 | ALDH1A1 (0.44) | DRD2DRD4ALDH1A1HIF1AKDM4E | |
| SCHEMBL886800 | 0.81 | MAPK8 (0.39) | MAPK8DRD2DRD4DRD3ALDH1A1 | |
| SCHEMBL2063063 | 0.81 | MAPK8 (0.39) | MAPK8DRD2DRD4DRD3ALDH1A1 | |
| SCHEMBL886801 | 0.81 | MAPK8 (0.39) | MAPK8DRD2DRD4DRD3ALDH1A1 | |
| SCHEMBL886798 | 0.79 | ENPP2 (0.35) | RENALDH1A1ENPP2USP19BRD4 | |
| SCHEMBL2063270 | 0.78 | SIGMAR1 (0.44) | ALDH1A1KDM4E | |
| SCHEMBL2062942 | 0.78 | CYP2D6 (0.37) | DRD2DRD4DRD3RENALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008089005-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-07-24 | — | — | WO | claimed |
| WO-2008089005-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-07-24 | — | — | WO | disclosed |