Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.34 |
| ▸ | PTGIR | P43119 | 2/20 | 0.34 |
| ▸ | BCL9 | O00512 | 1/20 | 0.34 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2062941 | 0.92 | KDM4E (0.38) | KDM4ERECQLALDH1A1TSHRLMNA | |
| SCHEMBL884275 | 0.89 | ALDH1A1 (0.35) | ALDH1A1TSHRMAPTCYP3A4CYP2D6 | |
| SCHEMBL885607 | 0.88 | ALDH1A1 (0.38) | KDM4ERECQLALDH1A1TSHRLMNA | |
| SCHEMBL884926 | 0.87 | ALDH1A1 (0.44) | KDM4ERECQLALDH1A1TSHRLMNA | |
| SCHEMBL884402 | 0.85 | PTGIR (0.36) | KDM4ERECQLALDH1A1TSHRLMNA | |
| SCHEMBL885860 | 0.85 | KDM4E (0.39) | KDM4ERECQLALDH1A1TSHRLMNA | |
| SCHEMBL885566 | 0.84 | HTR1A (0.36) | KDM4ERECQLALDH1A1TSHRLMNA | |
| SCHEMBL884549 | 0.83 | REN (0.39) | KDM4ERECQLALDH1A1TSHRLMNA | |
| SCHEMBL2062724 | 0.82 | PTGIR (0.34) | KDM4ERECQLALDH1A1TSHRLMNA | |
| SCHEMBL2062403 | 0.81 | KDM4E (0.40) | KDM4ERECQLALDH1A1TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008089005-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-07-24 | — | — | WO | claimed |
| WO-2008089005-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-07-24 | — | — | WO | disclosed |