Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Ethylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | TTR | P02766 | 1/20 | 0.31 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.31 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethylene Glycol SCHEMBL2141203 | 0.97 | ALDH1A1 (0.57) | ALDH1A1KDM4ETSHRTTRPDK1 | |
| Ethylene Glycol SCHEMBL166383 | 0.97 | ALDH1A1 (0.57) | ALDH1A1KDM4ETSHRTTRPDK1 | |
| Ethylene Glycol SCHEMBL168491 | 0.97 | ALDH1A1 (0.57) | ALDH1A1KDM4ETSHRTTRPDK1 | |
| Ethylene Glycol SCHEMBL169649 | 0.97 | ALDH1A1 (0.57) | ALDH1A1KDM4ETSHRTTRPDK1 | |
| Ethylene Glycol SCHEMBL9421796 | 0.97 | ALDH1A1 (0.57) | ALDH1A1KDM4ETSHRTTRPDK1 | |
| Ethylene Glycol SCHEMBL170134 | 0.97 | ALDH1A1 (0.57) | ALDH1A1KDM4ETSHRTTRPDK1 | |
| Ethylene Glycol SCHEMBL2879076 | 0.97 | ALDH1A1 (0.57) | ALDH1A1KDM4ETSHRTTRPDK1 | |
| Tetrahydrofuran SCHEMBL18762867 | 0.97 | ALDH1A1 (0.57) | ALDH1A1KDM4ETSHRTTRPDK1 | |
| Tetrahydrofuran SCHEMBL11819032 | 0.97 | ALDH1A1 (0.57) | ALDH1A1KDM4ETSHRTTRPDK1 | |
| Ethylene Glycol SCHEMBL169225 | 0.97 | ALDH1A1 (0.57) | ALDH1A1KDM4ETSHRTTRPDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519314-B1 | Chain extended low molecular weight polyethylene glycols as electrostatic dissipating agents in polymer blend compositions | GOODRICH CO B F (US) | 1997-02-05 | — | — | EP | disclosed |
| US-5574104-A | POLYETHERURETHANE ANTISTATIC AGENTS | THE B. F. GOODRICH COMPANY (US) | 1996-11-12 | — | — | US | disclosed |
| EP-0519314-A2 | Chain extended low molecular weight polyoxiranes and electrostatic dissipating blend compositions based thereon | THE B.F. GOODRICH COMPANY (US) | 1992-12-23 | — | — | EP | disclosed |
| US-5149739-A | Improved flexural modulus, flexural strength and melt prcessability | THE BFGOODRICH COMPANY (US) | 1992-09-22 | — | — | US | disclosed |
| US-5032627-A | Adding spheres during polymerization | THE B. F. GOODRICH COMPANY (US) | 1991-07-16 | — | — | US | disclosed |
| US-5017629-A | Moldable low density thermoplastic composite with hollow glass spheres and the method for compounding | THE B F GOODRICH COMPANY (US) | 1991-05-21 | — | — | US | disclosed |
| EP-0390147-A2 | Method for reducing hollow glass sphere fracture in thermoplastic resin by in situ polymerization/extrusion | THE B.F. GOODRICH COMPANY (US) | 1990-10-03 | — | — | EP | disclosed |
| EP-0390148-A2 | Moldable low density thermoplastic composite with hollow glass spheres and the method for compounding | THE B.F. GOODRICH COMPANY (US) | 1990-10-03 | — | — | EP | disclosed |