Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 4/20 | 0.35 |
| ▸ | ACHE | P22303 | 2/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8855240 | 0.74 | LMNA (0.37) | ALDH1A1KDM4EHPGDMEN1KMT2A | |
| SCHEMBL8855272 | 0.67 | MAPT (0.37) | ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL9827664 | 0.64 | LMNA (0.39) | ALDH1A1KDM4EHPGDACHEATM | |
| SCHEMBL22945671 | 0.64 | HTR2A (0.35) | HTR2AACHEPDE3BPDE3AGAA | |
| SCHEMBL22945960 | 0.64 | POLB (0.36) | ALDH1A1HTR2AACHEMEN1KMT2A | |
| SCHEMBL21360735 | 0.63 | ERN1 (0.38) | ALDH1A1KDM4EHPGDHTR2AMEN1 | |
| SCHEMBL9309831 | 0.62 | ACHE (0.49) | ALDH1A1KDM4EHPGDACHEMEN1 | |
| SCHEMBL9052842 | 0.62 | DRD2 (0.45) | ACHE | |
| SCHEMBL13816288 | 0.61 | GAA (0.50) | ALDH1A1HTR2AACHEGAA | |
| SCHEMBL2953510 | 0.61 | GAA (0.59) | ALDH1A1HPGDMEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5654343-A | NITRIC OXIDE SYNTHESIS INHIBITOR; TREATING ENDOTOXIC SHOCK | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1997-08-05 | — | — | US | disclosed |
| EP-0676196-A1 | NITROGEN MONOXIDE SYNTHESIS INHIBITOR | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-10-11 | — | — | EP | disclosed |