Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 7/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.45 |
| ▸ | DRD4 | P21917 | 2/20 | 0.45 |
| ▸ | DRD3 | P35462 | 2/20 | 0.45 |
| ▸ | HTR5A | P47898 | 2/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | POLL | Q9UGP5 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7918368 | 0.76 | GID4 (0.41) | DRD2DRD4CYP2D6KDM4EALDH1A1 | |
| SCHEMBL7926481 | 0.75 | HTR1A (0.46) | HTR1AMEN1KMT2ACYP1A2DRD2 | |
| SCHEMBL21360735 | 0.74 | ERN1 (0.38) | MEN1KMT2ACA1CA2KDM4E | |
| SCHEMBL8900865 | 0.74 | TAS1R3 (0.43) | ACHEHTR1AMEN1KMT2ACYP1A2 | |
| SCHEMBL17014300 | 0.74 | HTR1A (0.55) | ACHEHTR1AMEN1KMT2ACYP1A2 | |
| SCHEMBL9052842 | 0.73 | DRD2 (0.45) | ACHEHTR1ADRD2 | |
| SCHEMBL9441289 | 0.71 | CYP1A2 (0.43) | HTR1AMEN1KMT2ACYP1A2DRD2 | |
| SCHEMBL9005283 | 0.71 | CA1 (0.56) | HTR1AMEN1KMT2ACYP1A2DRD2 | |
| SCHEMBL1011305 | 0.70 | HSD11B1 (0.54) | ACHEHTR1AMEN1KMT2ACYP1A2 | |
| SCHEMBL15773366 | 0.70 | ACHE (0.49) | ACHEHTR1ADRD2DRD3POLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102766190-B | Triptolide alcohol intermediate method of asymmetric synthesis | 兰州大学 | 2016-08-17 | — | — | CN | claimed |
| WO-2023179351-A1 | ASYMMETRIC SYNTHESIS METHOD OF 7-OXOTRIPTOPHENOLIDE AND USE THEREOF | 欣凯医药化工中间体（上海）有限公司 | 2023-09-28 | — | — | WO | disclosed |
| US-5286747-A | 1-alkyl-2-aminotetralin derivatives | Carlsson, Per A. E. (SE) | 1994-02-15 | — | — | US | disclosed |
| US-5214156-A | Central nervous system disorders, dopamime receptor activity | THE UPJOHN COMPANY (US) | 1993-05-25 | — | — | US | disclosed |
| EP-0334538-B1 | THERAPEUTICALLY USEFUL TETRALIN DERIVATIVES | THE UPJOHN COMPANY (US) | 1992-12-02 | — | — | EP | disclosed |
| EP-0407416-A1 | THERAPEUTICALLY USEFUL TETRALIN DERIVATIVES | THE UPJOHN COMPANY (US) | 1991-01-16 | — | — | EP | disclosed |
| WO-1989009050-A1 | THERAPEUTICALLY USEFUL TETRALIN DERIVATIVES | THE UPJOHN COMPANY (US) | 1989-10-05 | — | — | WO | disclosed |
| EP-0334538-A1 | Therapeutically useful tetralin derivatives | THE UPJOHN COMPANY (US) | 1989-09-27 | — | — | EP | disclosed |
| EP-0064964-B1 | THERAPEUTICALLY USEFUL 1-ALKYL-2-AMINOTETRALIN DERIVATIVES | Astra Läkemedel Aktiebolag (SE) | 1984-08-08 | — | — | EP | disclosed |
| US-4049701-A | ANALGESICS, ANTIINFLAMMATORY | AMERICAN HOME PRODUCTS CORPORATION (US) | 1977-09-20 | — | — | US | disclosed |
| US-4001326-A | ANALGESICS, ANTIINFLAMMATORY AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1977-01-04 | — | — | US | disclosed |
| US-4001331-A | ANTIINFLAMMATORY, ANALGESIC | AMERICAN HOME PRODUCTS CORPORATION (US) | 1977-01-04 | — | — | US | disclosed |
| US-3979434-A | ANALGESICS, ANTIINFLAMMATORY | AMERICAN HOME PRODUCTS CORPORATION (US) | 1976-09-07 | — | — | US | disclosed |
| US-3976696-A | ANALGESIC, ANTIINFLAMMATORY | AMERICAN HOME PRODUCTS CORPORATION (US) | 1976-08-24 | — | — | US | disclosed |
| US-3976693-A | ANALGESIC, ANTIINFLAMMATORY | AMERICAN HOME PRODUCTS CORPORATION (US) | 1976-08-24 | — | — | US | disclosed |
| US-3957872-A | ANALGESICS, ANTIINFLAMMATORY AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1976-05-18 | — | — | US | disclosed |
| US-3937736-A | ANALGESICS, ANTIINFLAMMATORY AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1976-02-10 | — | — | US | disclosed |
| US-3931328-A | CARBURETOR | AMERICAN HOME PRODUCTS CORPORATION (US) | 1976-01-06 | — | — | US | disclosed |