Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.44 |
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL8866452 | 1.00 | SIGMAR1 (0.44) | SIGMAR1DRD2OPRM1KCNH2 | |
| SCHEMBL4522775 | 0.89 | OPRM1 (0.40) | SIGMAR1OPRM1KCNH2 | |
| Fumaric Acid SCHEMBL8866223 | 0.82 | DRD2 (0.46) | SIGMAR1DRD2 | |
| Maleic Acid SCHEMBL8867832 | 0.82 | DRD2 (0.46) | SIGMAR1DRD2 | |
| Fumaric Acid SCHEMBL8866214 | 0.82 | DRD2 (0.46) | SIGMAR1DRD2 | |
| SCHEMBL9279009 | 0.76 | OPRM1 (0.42) | SIGMAR1OPRM1KCNH2 | |
| Fumaric Acid SCHEMBL8867300 | 0.72 | DRD2 (0.42) | SIGMAR1DRD2 | |
| Maleic Acid SCHEMBL8867286 | 0.72 | DRD2 (0.42) | SIGMAR1DRD2 | |
| Maleic Acid SCHEMBL8867278 | 0.72 | DRD2 (0.42) | SIGMAR1DRD2 | |
| SCHEMBL9252531 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5594000-A | THAT STIMULATE CENTRAL MUSCARINIC ACETYLCHOLINE RECEPTORS, ANALGESICS, NERVOUS SYSTEM DISORDERS, MENTAL ILLNESS | ASTRA AB (SE) | 1997-01-14 | — | — | US | disclosed |
| US-5412096-A | Treatment of senile dementia, Alzheimer*s disease, cholinergic activators | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1995-05-02 | — | — | US | disclosed |
| EP-0490901-A1 | NOVEL SPIROFURANE DERIVATIVES | Astra Aktiebolag (SE) | 1992-06-24 | — | — | EP | disclosed |
| WO-1990015804-A1 | NOVEL SPIROFURANE DERIVATIVES | FISONS CORPORATION (US) | 1990-12-27 | — | — | WO | disclosed |